The Military Guard were already on board when the Adrian arrived at Portsmouth from the river (Thames) on Tuesday 6th April 1830.
The Guard consisted of Ensign Reynolds of 17th regiment with 29 non-commissioned officers and privates under command of A.M. Robinson of 26th regiment.
The Prisoners were tried in counties throughout England. Quite a few had been tried at the Old Bailey and imprisoned in Newgate before being sent to the Hulks at Portsmouth. Some of those sent to the Hardy Hulk from Newgate were embarked on the Adrian on 7th April - Lawrence Martin, Edward Sampson, James Browne, George Walker, Joseph Thomas, John Harris, John Jacobs, George Kirby and Richard England.
The Adrian departed Portsmouth on 27th April 1830.
SURGEON GEORGE H. WEATHERHEAD
George H. Weatherhead kept Medical Journal from 31st March to 20th August 1830 - In the Surgeon's general remarks he noted that the number of convicts received from the hulks at Portsmouth and embarked on board of the Adrian was 168. Their general condition, and appearance, was unobjectionable. The occurrences on board during the voyage were so unimportant as not to afford occasions for remark. Only two cases of any consequence happened: a case of midwifery, somewhat tedious in its accomplishment, and that of John Barker, who was nearly dying from inanition
On 30th May, Mrs Smith wife of Sergeant Smith of the Guard gave birth to her first child, a daughter. Although there was the complication of the cord being wrapped around the baby's neck, both mother and baby survived. Dr. Weatherhead vaccinated the child in July 1830. 
The Adrian arrived in Port Jackson on Friday 20 August 1830, a direct passage of 115 days.
By the 1820s and 30's the convict indents often included quite a lot of information about each prisoner than they had in earlier years.
The Indent of the Adrian includes each of the convicts' name, age, education, marital state, religion, native place, trade or calling, offence where and when tried, sentence, prior convictions, physical description, how disposed of (assignment) and occasional colonial notes such as ticket of leave numbers date of death or colonial sentences.
The Sydney Gazette reported: The prisoners by the Adrian were landed on Monday, and those by the Marquis of Huntley on Thursday, making in all a total of three hundred and ninety five. They are mostly fine powerful men, and will prove an acquisition to our up country friends, having a considerable portion of agriculturalists in their number
Two days after the men were landed they were confronted with a stark reminder of the consequences of taking to the bush when notorious bushranger 'Bold Jack Donohoe' was shot and killed by the Mounted Police near Campbelltown. This did little to deter David Pegg who soon after arrival had been assigned far up the Hunter Valley to the vicinity of Pages River. Before many months had passed he joined other absconders Richard Anscomb and Thomas Thompson to rob the house of William H. Warland. He had only been in the colony a little over twelve months when he died a gruesome death on the gallows in Sydney.
NOTES AND LINKS
1). Return of Convicts of the Adrian assigned between 1st January 1832 and 31st March 1832 (Sydney Gazette 14 June 1832).....
Charles Bevan - Carpenter and joiner assigned to Potter Macqueen at Segenoe
James Brown - Plasterer and labourer assigned to J.L. McGillivray at Cook's River
John Cook - Plasterer and labourer assigned to George McLeay at Brownlow Hill
Thomas Dorrell - Ploughman assigned to John Mann at Williams River
John Fletcher - Jeweller assigned to John Dawson in Sydney
John Fisher - Carman assigned to Cornelius Prout in Sydney
Michael Hogan - Shoemaker assigned to Andrew Brown at Bathurst
2). National Archives - Reference: ADM 101/1/5 Description: Medical journal of the convict ship Adrian from 31 March to 20 August 1830 by G H Weatherhead, surgeon and superintendent.
3). Convict Ships bringing detachments of the 17th regiment.....
 Ancestry.com. UK, Royal Navy Medical Journals, 1817-1857. Medical Journal of George Hume Weatherhead on the voyage of the Adrian in 1830. The National Archives. Kew, Richmond, Surrey.
 Bateson, Charles. Library of Australian History (1983). The Convict Ships, 1787-1868 (Australian ed). Library of Australian History, Sydney : pp.348-349, 386