The Mangles departed London for Cork on 10th October 1825.
In September at Dublin it was reported that an attempt had been made by some of the convicts on board the Hulk stationed in Kingstown harbour to make their escape from that vessel. One of the convicts was shot dead in the attempt and one made his escape. The following week forty six of the convicts were put on board the Clementina schooner in order to be conveyed to the Hulk at Cork, previous to their transportation.
At Cove they may have been held in the Cork Depot or the Surprise Hulk to await transportation. After embarking prisoners at the Cove of Cork the Mangles departed on 23rd October 1825. 
Surgeon Thomas Braidwood Wilson
Thomas Braidwood Wilson kept a Medical Journal from 31st August 1825 to 18th February 1826. It is written in Latin. 
The Mangles came direct without touching anywhere and arrived in Port Jackson on 18 February 1826 with 189 male prisoners in good health. According to the Sydney Gazette, one convict died (who was half dead on embarking), on the passage out.Thomas B. Wilson's Journal states two deaths. Michael Lahey is listed in the indents as having died on the passage out.
The prisoners were mustered on board on Tuesday 25th February by the new Colonial Secretary Alexander McLeay. The indents include the name, age, education, religion, marital status, family, calling, native place, offence, when and where tried, sentence, former convictions, physical description and where assigned on arrival. There is also occasional information about colonial sentences and against each name is a remark regarding their conduct on the voyage out. Most of the men behaved well. Thirty six year old shopkeeper Anthony Mitchell's conduct was considered excellent while two young men Patrick Egan age 14, Charles Kenny aged 19 both behaved badly on the voyage. Both these lads were later in trouble as well. Charles Kenny was transported to Norfolk Island and Patrick Egan had an extra 18 months added to his sentence for a robbery at Maitland.
The youngest prisoners on board were William Byrne 16, Patrick Egan 14, John Haley 16, William Johnstone 14, Michael Mangin 15, John McCormick 14, John McCabe 14, Michael Rafferty 16, Michael Reardon 14, John Regan 16 and John Todd 16. None of these boys were assigned to settlers on arrival. They were probably sent to the Carter's barracks after disembarking.
Some of the prisoners were assigned to the Australian Agricultural Company soon after arrival including brothers James and Thomas Burke; James Couglan, Patrick Doyle; John Graham; Richard Handwright; Patrick Hayden; John Linskey; Timothy Leary; James Leonard; James McGennis, John Moore; Francis McNally; Thomas McGuire; Christopher Quinn; Denis Riorden; Patrick Sheridan and Michael Willson. This was before the company took over the Coal mines at Newcastle. They may have been employed on Company land at Port Stephens and northward as shepherds and hutkeepers.
The Headquarters of the 57th came out on the Mangles and Lieutenant-Colonel Shadforth, wife Frances nee Hindson and daughter Frances were passengers. The Band of the 57th came on the Sesostris. Thomas Shadforth had been wounded at the battle of Albuera in Spain and promoted to major. He was promoted lieutenant-colonel in August 1819. His eldest son Henry John Tudor, a lieutenant in the 57th, arrived in the Minstrel in August 1825, and the second son, Thomas, who had been made an ensign in the 57th in 1825, arrived about the same time. Another son, Robert William, after completing his education in England, arrived at Sydney in the Sovereign in May 1835. Lieutenant-Colonel Shadforth remained in Australia for the rest of his life.(2) Fifty seven year old Mangles prisoner Joshua Wolverstone a groom from Armagh was assigned to Lieutenant-Colonel Shadforth on arrival.
Captain John Coghill
This was John Coghill's last voyage as Captain of the Mangles. Soon after arrival he was accused of smuggling two casks of spirits from the Mangles while she lay in Sydney Harbour. His outrage at the accusation can be read in the correspondence below. He remained in Australia where he became a settler and the command of the Mangles devolved to the chief mate, William Carr.
Mr. John Cogill to Colonial Secretary McLeay.
Sir, Sydney, 9th May, 1826.
Having heard, with mingled astonishment and regret, that Sir Thomas Brisbane left behind him a representation, in which I am charged with being a Smuggler, I trust I shall stand excused for the liberty I have taken in requesting that you will be pleased to submit the accompanying documents to His Excellency Governor Darling, with the expression of my respectful hope that they may be transmitted to His Majesty's Government in England, where I have reason to believe a charge against me has been sent similar to the undeserved one, left in this Colony.
No human being can be more earnestly solicitous to avoid giving trouble than myself; but I owe it to my character, to my friends, and to my family, not to submit in silence to the unmerited attack, of which I complain; and I cannot persuade myself, when His Excellency Governor Darling shall have read my statement of facts and the accompanying clear evidence in support and corroboration of that statement, but that he will consider it due to Justice and the maintenance of the candour and unsullied honor of his own character to direct that I may be furnished with a copy, of what may have been written to the injury of mine, thereby inflicting the greatest injury, which a man of integrity can sustain.
I have, etc, John Cogill
Select here to read more about the charges against John Coghill (HRA, Series 1, Vol. XII, p.331).
Departure of the Mangles for England
The Mangles was chartered by Cooper and Levey to take a shipment of wool back to England. The cargo was said to be worth £20,000. Wealthy merchant Solomon Levey returned to England on the Mangles to make arrangements for extensive mercantile investments. Mr. McArthur also sent home an extensive assortment of wool by the Mangles.
2). Three men were convicted under the Insurrection Act - Patrick Connolly and Garrett Fitzgerald from Limerick and Patrick McKenny from Westmeath.
3).The Recorder's Court sat on Saturday last: Aldermen Montgomery, C.P. Archer, and Sir T. Whelan, on the Bench. Christopher Fox stood indicted for stealing a gold seal, the property of James Connolly, Esq. Mr. William Connolly examined by Mr. Bethel - Proved the identity of the seal, and that the prisoner lived with him at his house in Stephen's green in the capacity of a groom, for the space of four months, during which time he missed several articles of place, and other articles, his property. The Jury, under the direction of the Learned Recorder, found the prisoner guilty, and he was sentenced to 7 years transportation. - Freeman's Journal 12 July 1825
4). William Rainsford was indicted for stealing a barrel of wheat from Mr. Francis Burke of Townsend street, who deposed that for some time, he had reason to suspect that the stock of wheat on his loft was decreasing unfairly for some time; he discharged some of his draymen in consequence, and set a watch on the premises; the prisoner lived in his service as a drayman for twelve months; he had the highest opinion of his correctness; some days ago he received information that a sack of wheat had been deposited in the house of one Magrath, a barber in Stocking lane, whither he proceeded, accompanied by a peace officer; the wheat in the sack corresponded with that on his lofts; he had two of his draymen, the prisoner and Patrick Cullen, apprehended; Cullen became an approver, and on his examination before the Police Magistrates, admitted that he was concerned with prisoner in the robbery; his evidence on the trial being admitted he deposed - That the day before the robbery of the wheat which was the subject of the present trial he brought a barrel of wheat to a person named Cummins in Thomas street, who gave him thirty one shillings as payment for it; half of which he gave to the prisoner at the bar, and that on the following day he removed, on his dray, from his master's stores, the sack of wheat which was deposited at Magrath's til an opportunity might offer for its disposal. The prisoner having offered nothing in his defence, was found guilty and received sentence of transportation for seven years. - Freeman's Journal 8 August 1825
5). Voyages of the convict ship Mangles included those in 1820, 1822, 1824, 1826, 1828, 1833, 1835 (VDL), 1837 and 1840
6). Eleven convict ships brought prisoners to New South Wales in 1826 - Marquis of Hastings, Sir Godfrey Webster, Mangles, Sesostris, Lady Rowena, Regalia, Marquis of Huntley, England, Boyne, Speke and Phoenix
7). Return of Convicts of the Mangles assigned between 1st January 1832 and 31st March 1832 (Sydney Gazette 14 June 1832; 21 June 1832; 28 June 1832).....
Thomas Dovan (Doran) Coachman and servant. Assigned to Andrew Marsh at Parramatta
Patrick Flanagan Labourer assigned to Michael Bryan at Airds
Patrick Farrell Weaver and labourer assigned to William Smith at Parramatta
 Bateson, Charles, Library of Australian History (1983). The convict ships, 1787-1868 (Australian ed). Library of Australian History, Sydney : pp.346-347
 Ancestry.com. UK, Royal Navy Medical Journals, 1817-1857. Medical Journal of Thomas Braidwood Wilson on the voyage of the Mangles in 1826 . The National Archives. Kew, Richmond, Surrey.
 National Archives - Reference: ADM 101/47/4 Description: Medical and surgical journal of the convict ship Mangles, for 31 August 1825 to 28 February 1826 by T B Wilson MD, Surgeon and Superintendent, during which time the said ship was employed in a voyage to New South Wales.