The Nautilus departed Dublin on 17th September 1839.
Passengers included Lieut. Mirran 96th regt., Ensign Lake 28th regiment, 28 rank and file of the 28th and 96th regiment, seven women four children and four free settlers.
Surgeon George McClure
George McClure kept a medical journal from 4 September 1839 to 15 March 1840 -
All of the prisoners were in a healthy constitution on embarkation, except one man, Cornelius Cavenagh, who later died. He was debilitated, but in consequence of his age and his entreaties to be allowed to accompany his comrades, the surgeon agreed to take him. Cavenagh was however on the sick list the most of the voyage and at last died when about a hundred miles from Sydney.
Some of the men were treated early on for ophthalmia and Mrs. Bishop, wife of a soldier suffered a miscarriage during the passage and was thereafter treated by the surgeon. There were none on the sick list when the ship arrived in Sydney, nor on the voyage to Norfolk Island. The surgeon thought that there was never a party of convicts landed in a more healthy or sound condition. 
The Nautilus arrived in Port Jackson in February 1840 and departed Port Jackson for Norfolk Island on Saturday 22nd February 1840with 199 convicts.
Convicts who arrived on the Woodbridge in February 1840 were also sent to Norfolk Island at the same time as the men of the Nautilus.
Passengers to Norfolk Island included Capt. Alexander Maconnochie and family.
Alexander Maconochie had been appointed superintendent at Norfolk Island and took up his duties in March 1840. Alexander Maconochie was a penal reformer. His notions of penal science rested on the beliefs that cruelty debases both victim and the society inflicting it and that punishment for crime should not be vindictive but designed to strengthen a prisoner's desire and capacity to observe social constraints.