The Seaflower departed Calcutta on 20th February 1820 with merchandise and ten prisoners of the Crown.
They arrived in Hobart in April 1820. 
Passengers included Captain Carleton of the Hon. East India Company's Service, Mr. Williams and Mr. Blany.
Ensign Lewis of the brig Governor Macquarie who had accompanied John Oxley to Port Davey and Macquarie Harbour came to Hobart on the Seaflower having transferred from the Governor Macquarie while at sea. 
The Seaflower sailed for Port Jackson on 24 April 1820
Ten prisoners from Calcutta arrived in Port Jackson on the Seaflower on 30th April 1820 -
William Farrell, Soldier
Patrick Burnett, Soldier
William Muston, Soldier
Wilson Johnson Appleyard. From Northampton. Formerly a clerk in transport office and purser to the Shipley on her voyage to New South Wales. Sent to Newcastle in 1820. Received a Certificate of Freedom in 1826
John Perry Bowers, Dealer
Peter McLauglin, Soldier
John Head, Soldier
Michael Kean/ Kain, Soldier. In a letter in a Sydney newspaper in 1826 describing his experiences as a convict, Michael Kean referred to himself as a Botany Bay Hero
John Wheland, Soldier
William Yates. First arrived as a convict on the Lord Sidmouth in 1819 and effected his escape to India and was being returned to New South Wales.
The prisoners were mustered in Sydney by Colonial Secretary Mr. Campbell on 2nd May 1820.