It was reported on 10th February that the Guildford was being fitted up in the Thames River in preparation for taking male prisoners to New South Wales.
Departure of the Guildford
The Guildford departed London on 24th March and Plymouth on 31 March 1827.
The Guard consisted of Captain John Douglas Forbes, Surgeon Hamilton and 30 men of the of 39th regiment.
Living Conditions on the Ship
Charles Linton kept a Medical Journal from 7 March to 15 August 1827. His detailed report on ventilation was included in the journal:
The width and height of the Guildford between decks was very favourable for keeping the prison well ventilated. I have had difficulty however in getting the windsails mounted and kept property trim and attended to during the passage - from the criminal want of activity in the Master and his Mates, from whom I received very little efficient assistance of any kind during the whole voyage. I consequently was obliged on all cases of the most trifling nature to attend to every minute detail myself in order for the preservation of health.
I regret to say that the hospital was very imperfectly ventilated during almost one third of the first part of the passage in consequence of the ship having a forecastle deck over the hospital. The grated scuttle on the upper deck of the Hospital being rendered completely useless from the sailors being allowed to berth under the forecastle by this means their scuttle was almost constantly closed up by the sailors. It was a nuisance I could not get remedied before our arrival at the Equator notwithstanding repeated remonstrances and applications to the Master on the subject. I proposed to have had this remedied before the Guildford sailed from Sheerness, having recommended a wooden square tube to be carried up from the Hospital Scuttle to that of the Forecastle by which means constant ventilation could have been ensured and all communication with the seamen cut off. The Master however refused to comply with this request and as the Dispatch had arrived, I had not time to communicate with the Navy Board on the subject. When this tube was at length put up, I found great advantage from its use and subsequently the vessel was kept in the most perfect state of ventilation. 
One prisoner, John Towns died on the voyage out (on 25th June) after suffering dysentery.
Arrival in Port Jackson
One hundred and eighty-nine prisoners arrived at Port Jackson on 25 July 1827 after a voyage of 116 days.
Muster of Convicts
The prisoners were mustered on board by the Colonial Secretary Alexander McLeay on 28th July. Convict indents include the name, age, education, religion, marital status, family, native place, occupation, offence, when and where tried, sentence, prior convictions, physical descriptions and to whom assigned on arrival.
Sixteen prisoners were under the age of 16 years of age. The youngest two were William Johnson and George MacFarland who were only 14 years old.
3). Captain John Douglas Forbes was the son of Bartholomew Forbes Esq,. He was appointed Ensign in 39th regiment on 17 April 1823. He kept a Diary on the voyage of the Guildford which is available at NLA Australia.
Captain J.D. Forbes was Commandant of the Mounted Police 1830 - 1832; he was commended for his zeal and efficiency in that position. He played a prominent part in colonial life. He departed for India with the 39th regiment on the John on 26th July 1832 and died at sea age 33, on his passage from Madras to England on the Protector when in command of invalids on 16 June 1837.
4). Select here to find out more about Bushranger William Atkinson who arrived as a convict on the Guildford
5). Henry Phantom, John Andrews, and William Andrews were all transported on the Guildford. Select Untold Lives Blog, British Library to find out more about their crimes.
Sophia departed Dublin 15 September 1828 departed Dublin 15 September 1828 - Major Thomas Poole
10). National Archives. Reference: ADM 101/31/4 Description: Medical and surgical journal of His Majesty's Convict Ship Guildford for 7 March to 15 August 1827 by Charles Linton, surgeon and superintendent during which time the said ship was employed in the river Thames and passage to New South Wales.
1. Ancestry.com. UK, Royal Navy Medical Journals, 1817-1857. Medical Journal of Charles Linton on the voyage of the Guildford in 1827. The National Archives. Kew, Richmond, Surrey.
2. Bateson, Charles Library of Australian History (1983). The convict ships, 1787-1868 (Australian ed). Library of Australian History, Sydney : pp.346-347, 385